MOTS-c

As a mitochondrial-derived peptide, MOTS-c has become a valuable tool for studying systemic metabolic regulation and intracellular signalling. Its origin within mitochondrial DNA, rather than nuclear DNA, has made it a useful model for investigating mitochondria-to-nucleus communication and metabolic signalling pathways.

Research has explored MOTS-c’s role in energy metabolism, glucose homeostasis, AMPK signalling, oxidative stress responses, and adaptive cellular processes. Ongoing studies are investigating its potential relevance to aging biology, metabolic regulation, and cellular stress-response mechanisms.