PE-22-28

Developed as a stabilized analog of spadin, PE-22-28 has attracted scientific interest for its ability to modulate TREK-1 potassium channel activity. Its pharmacological profile has made it a valuable research tool in neuroscience, electrophysiology, and peptide biology.

Preclinical investigations have explored PE-22-28 in relation to TREK-1 channel inhibition, synaptic plasticity, neuronal adaptation, and molecular pathways involved in neurophysiology. Research has also examined its interactions with intracellular signalling mechanisms associated with neuronal function, neuroplasticity, and cellular communication under controlled laboratory conditions.

Research Applications

• TREK-1 potassium channel studies
• Ion channel physiology research
• Neuronal excitability investigations
• Synaptic plasticity studies
• Neuroplasticity pathway analysis
• Cellular electrophysiology research
• Molecular neurobiology and peptide pharmacology research