ARA-290

ARA-290 selectively binds and activates the innate repair receptor (IRR), a receptor complex composed of the erythropoietin receptor (EPOR) and the β-common receptor (CD131). This receptor is upregulated following tissue injury and is involved in regulating the body’s repair, protective, and anti-inflammatory responses.

ARA-290 was made to separate the regenerative and protective actions of EPO from its red blood cell–stimulating effects. Through selective activation of the IRR, ARA-290 triggers signalling pathways that promote anti-inflammatory, anti-apoptotic, and tissue-repair functions without altering red blood cell levels.

Its mechanism of action primarily involves suppression of pro-inflammatory signalling, especially the NF-κB pathway, a major regulator of inflammatory activity. Inhibiting this pathway decreases the release of inflammatory cytokines such as TNF-α and IL-6. 

Studied in research involving peripheral neuropathy, nerve repair, inflammation regulation, mitochondrial activity, and tissue resistance to stress-related damage.