VIP

VIP mediates many of its biological effects through VPAC1 and VPAC2 receptors, both of which are G protein-coupled receptors. Activation of these receptors stimulates adenylyl cyclase, leading to increased intracellular cyclic adenosine monophosphate (cAMP) levels and regulation of downstream signalling pathways. Additional signalling mechanisms, including calcium-associated pathways, may also be involved depending on the experimental system.

Research Applications

• Neuropeptide signaling
• VPAC1 and VPAC2 receptor biology
• cAMP-mediated intracellular signalling
• Gastrointestinal physiology and secretion
• Vascular regulation and vasodilation
• Respiratory physiology and bronchodilation
• Immune system modulation
• Circadian rhythm and neuroendocrine research